Pyxiloricaria menezesi is the only species of the monotypic genus Pyxiloricaria, a genus of the family Loricariidae of catfish (order Siluriformes).

[1] This species is endemic to Brazil where it occurs in the Paraguay River drainage.

[1] P. menezesi inhabits sandy substrates and is sympatric with representatives of the genus Pseudohemiodon.

[1] Pyxiloricaria menezesi reaches a length of 14.0 centimetres (5.5 in) SL.

[2] The phylogenetic position is uncertain; although it is thought to be closely related to Pseudohemiodon, it shares with Loricaria filamentous lips, inconspicuous fringed barbels on the lower lip, and shorter maxillary barbels.