Pyxine profallax is a species of corticolous (bark-dwelling), foliose lichen in the family Caliciaceae.

The type specimen was collected in 1975 by Syo Kurokawa near Woitape (Central Province, Papua New Guinea) at an elevation of about 1,600 m (5,200 ft).

[2] The loosely attached grey, whitish, or brownish-grey thallus of Pyxine profallax reaches a diameter of up to 5 cm (2 in).

Neither soredia nor isidia occur in this lichen, but it does have ascomata of the obscurens-type, measuring 0.5–1 mm in diameter, with black discs.

[2] Pyxine profallax contains norstictic acid as a major compound, testacein (submajor), and atranorin as a minor secondary metabolite.