[4] Qalb Loze lies at an elevation of 670 meters in the Idlib Governorate on the A'la Mountain (Jabal Summaq) plateau, a remote hilly region of western central part of the northern Syrian limestone massif, a few kilometers from the Turkish border.

[8][11] It is strikingly similar in architectural style and craftsmanship to the large pre-Islamic Syrian churches in Turmanin, Androna, Ruweha (de:Ruweiha), and Karatin, which may have been built by the same workshops or guilds.

[12][13] Gertrude Bell, the intrepid Middle Eastern diplomat, explorer and archaeologist, described this church as "...the beginning of a new chapter in the architecture of the world.

[17] During the ongoing Syrian civil war, the Druze inhabitants of Qalb Loze have refrained from participating in the fighting between opposition rebels and government forces.

Relations between the village's residents and the Sunni Muslim majority in the area are strong and most oppose the government of Bashar al-Assad.

Qalb Loze has provided a safe haven for Druze deserters from the Syrian Army, clinics for wounded rebels, and shelter for local refugees fleeing the violence in their towns and villages.