It is 40 kilometres (25 mi) westnorth-west (WNW) of the Sydney central business district, in the local government area of the City of Blacktown.

[3] Alan Sharpe, in his "Pictorial History Blacktown and District" (referenced below) on page 84 has no mention of the historic town plan of July 1790.

It is said they were responsible for burying the dead in simple cairn marked graves that lay in the fields, paddocks and creeks who were all victims of the 1804 uprising and rebellion.

The origin of the name is unclear and the next references are more than sixty years later when Thomas Harvey used it for his property in what is now western Quakers Hill.

[5] In the 1960s, Sydney's suburban sprawl reached the Quakers Hill area and the five acre farms surrounding the village began to be subdivided.

In 1994, HMAS Nirimba, a naval training property on the western side of the suburb, was decommissioned and converted into an educational precinct.

[2][7] On 18 November 2011, an early morning fire at Quakers Hill Nursing Home killed 11 elderly residents, seriously injured others and caused the evacuation of up to 100 people.

[8] A nurse working in the home, 36-year-old Roger Kingsley Dean, was charged for the fire and the deaths it caused and was sentenced to life imprisonment without the possibility of parole.

[13] Bus services connect to Sydney Metro network at Tallawong, Rouse Hill and Bella Vista stations.

The Westlink M7, which links the suburb directly to all major routes in and out of the greater Sydney region, opened in December 2005.

The western side of the railway line predominantly has houses on standard residential blocks, some built when HMAS Nirimba was an active naval base, others through the 1960s and 1970s.