The most recent incarnation of the quartet was formed in the year 2000, while studying at the Walter Stauffer Academy in Cremona with Salvatore Accardo, Rocco Filippini, and Bruno Giuranna.

The ensemble, with the current members since 2002, continued their studies with Piero Farulli of the Quartetto Italiano at the Fiesole School of Music and with Hatto Beyerle of the Alban Berg Quartet.

Following a concert at the Wigmore Hall, the British magazine The Strad wrote, "Dynamic contouring was as sleek and elegant as an Armani suit, and it tailored the music to perfection."

In Australia, the quartet was acclaimed as the "glory of the Perth Festival" and the Süddeutsche Zeitung described them as “one of the most exciting quartets of the current generation.” Radio and television stations around the world (such as RAI, WDR, BBC, VRT, SDR, and ABC) regularly broadcast the Quartetto di Cremona concerts in repertoire ranging from the early works of Haydn to contemporary music, particularly works of Fabio Vacchi, Lorenzo Ferrero, Helmut Lachenmann, and Silvia Colasanti.

The group collaborates with world-renowned artists such as Bruno Giuranna, Massimo Quarta, Enrico Dindo, Carbonare Alessandro, Andrea Lucchesini, Pietro de Maria, Gloria Campaner, Angela Hewitt, Ivo Pogorelich, Lilya Zilberstein, Cédric Tiberghien, and Pieter Wispelwey.