From there until its terminus in Sherbrooke, the A-10 is called the Autoroute des Cantons-de-l'Est (Eastern Townships Expressway), a reference to the historic name given to the region east of Montreal and north of the U.S. border.

The A-10 serves as an important link for commuters travelling to downtown Montreal from suburban South Shore communities via the Champlain Bridge.

Bus lanes run in both directions along the median for four kilometers between the southern end of the Champlain Bridge and Milan Boulevard.

[1] The 116 km (72 mi) long Autoroute de l'Est (Eastern Expressway) was opened to traffic in December 1964.

The Autoroute Bonaventure through Montreal opened in 1967 to link approach roads to Expo 67 with the Champlain Bridge.

As Canada had not yet adopted the metric system, exit numbers referenced the distance in miles from the southern end of the Champlain Bridge.

The city of Montreal announced in January 2013 that it would take over the SHM's responsibilities, citing concerns over transparency.

[3] The Société du Havre de Montréal (SHM) transformed the autoroute into an urban thoroughfare as part of a broader project to redevelop Montreal's harbourfront.

[4] Demolition of the autoroute’s elevated stretch began in July 2016 and the new Bonaventure Park was completed in September 2017.

Doing so would create a new and more direct limited-access highway link between Maine, the Maritime Provinces through New Brunswick Route 1, and Quebec.