The gap in the highway was filled on November 26, 2012, and the two-lane freeway opened for traffic on the full 159 km (98.8 mi) length.

It was originally envisioned that the A-50 would extend over 400 km from L'Isle-aux-Allumettes at the Ontario border through Saint-Jérôme and Joliette along the Route 148 and 158 corridors to Berthierville and a junction with the A-40.

Mirabel's rapid decline as an air hub as well as the Quebec government's decision in the 1970s to impose a moratorium on new autoroute construction resulted in a significantly truncated route for the A-50.

Construction was completed in the fall of 2007 on the road that connects Highway 148 west of the Aylmer and Hull sectors to the A-50 at the Boulevard des Allumettières interchange.

In addition, west of the current terminus, a four-lane at-grade expressway continues as Route 148 into the Aylmer section of Gatineau; it may become part of A-50 in the future.

[8] In 2022, following the death of Montreal Canadiens hockey legend Guy Lafleur (who was a native of Thurso), the Quebec government openly considered renaming the highway after Lafleur following a request made by the Minister Responsible for the Outaouais Region Mathieu Lacombe and by Thurso mayor Benoit Lauzon.