[3] Rania attended the New English School in Kuwait and subsequently received a degree in business administration from the American University in Cairo.

[13] She has said that education is a tool for individuals to empower themselves, allows the poor to improve their lives, and is an investment Jordan makes to protect its people from being exploited and falling victim to extremist ideology.

The deaths of two children in Amman as a result of child abuse in early 2009 led Rania to call for an emergency meeting of government and non-government (including JRF) stakeholders to discuss where the system was failing.

[31] In early 2002 Rania joined the board of directors of the International Youth Foundation, based in Baltimore, Maryland, in the United States.

[34] As a longtime supporter of the Global Campaign for Education (GCE),[35] Rania met with children and inspirational women in South Africa, both in the cities of Johannesburg and Soweto, in March 2009.

[40] On 20 August 2009, Rania co-founded and led the launch of the "1GOAL: Education for All" campaign alongside Gary Lineker, and with the help of top international footballers at Wembley Stadium, London.

[45] Rania has played a significant role in reaching out to the global community to foster values of tolerance and acceptance, and increase cross-cultural dialogue.

[52] The UN Foundation builds and implements public-private partnerships to address the world's most pressing problems, and broadens support for the UN through advocacy and public outreach.

[55] In October 2020, Rania was named as a member of the Earthshot Prize Council, an initiative of Prince William to find solutions to environmental issues.

[58] On 30 March 2008, Rania launched her own YouTube channel, initially to invite viewers to give their opinions of the Middle East and talk about stereotypes they may have of Arabs and Muslims.

[59] Between 30 March and 12 August (International Youth Day), Rania posted videos on YouTube in which she asked people to send her their questions about Islam and the Arab world.

[61] International personalities such as Dean Obeidallah,[62] Maz Jobrani,[63] and YouTube star Mia Rose[64] also contributed videos to the campaign.

She appeared alongside The Black Eyed Peas member will.i.am in the video, "End Poverty – Be the Generation,"[66] which urged world leaders to keep the promises they made in 2000 at the United Nations Millennium Summit.

To coincide with the visit of Pope Benedict XVI to Jordan on 8 May 2009, Rania started using the microblogging website Twitter with the username @QueenRania.