[7] Its trustees selected the Queen's College name to commemorate a school established in North Carolina in 1771, before being disallowed by the British Crown the next year.

[7] In 1930, it merged with Chicora College for Women, previously located in Columbia, South Carolina.

Queens is a member of the NCAA's Division I program nationally; regionally, the Royals participate in the ASUN Conference.

Men's athletic teams include baseball, basketball, cheerleading, cross-country, golf, lacrosse, rugby,[12] soccer, swimming, tennis, track & field, volleyball, and triathlon.

Women's athletic teams include basketball, cheerleading, dance, cross-country, equestrian, field hockey, golf, lacrosse, rugby,[12] soccer, softball, swimming, tennis, track & field, volleyball, and triathlon.