The final presenter was Paddy McGuinness, with team captains Sam Quek and Ugo Monye.

Joining presenter Sue Barker and captains Matt Dawson and Phil Tufnell were Pat Cash, David Coulthard, Laura Davies and Michael Johnson.

On 29 September 2012, Tim Baillie, Jade Jones, Laura Kenny, Greg Rutherford and Etienne Stott partook.

On 7 September 2016, the Olympic Champions special featured gold medal winners, including Callum Skinner.

As well as looking back through the archives, A Question of Sport at 50 saw a number of sportspeople recount their memories, these included: Jessica Ennis-Hill, Colin Jackson, and Denise Lewis.

Matt Dawson captained a team composed of Laura Davies and Beth Tweddle, while Phil Tufnell led Ally McCoist and Martin Offiah.

Following the programme producers' decision in 2021 to "refresh" the Question of Sport by introducing a new host (Paddy McGuiness) and revising the structure of the quiz there was an ensuing drop-off in audience figures and, in December 2023, after two series of the revamped production, the BBC announced a decision to "shelve" the programme citing "inflation and funding challenges".

Sports action is shown and contestants are asked questions about details of what they have just seen, e.g. "What colour hat was a certain person wearing?"

[15] A Question of Sport's first captains were boxer Henry Cooper and rugby union player Cliff Morgan.

[15] Captains include: 5 rugby union players: Cliff Morgan (1970–1972 and 1974–1975), Gareth Edwards (1979–1982), Bill Beaumont (1982–1996), Matt Dawson (2004–2021) and Ugo Monye (2021–2023) 3 cricketers: Fred Trueman (1976–1977), Ian Botham (1988–1996) and Phil Tufnell (2008–2021) 2 jockeys: Willie Carson (1982–1984) and Frankie Dettori (2002–2004) 2 footballers: Emlyn Hughes (1979–1982, 1984–1988) and Ally McCoist (1996–2007) 1 boxer: Henry Cooper (1970–1972, 1974–1977 and 1979) 1 long-distance runner: Brendan Foster (1977 and 1979) 1 snooker player: John Parrott (1996–2002) 1 hockey player: Sam Quek (2021–2023) Over the years there have been several guest captains standing in for one of the regulars when they have other commitments.

A Question of Spit was a short segment aired in 1988 as part of the inaugural Red Nose Day telethon, featuring Daley Thompson, Barry McGuigan and Mike Gatting forming a team, with their opponents being their own Spitting Image puppets, captained by an Emlyn Hughes puppet.

Presented by Barry Landy, the show featured two teams consisting of Stuart Hodge, Rory Wilde, Phil Peacock, Steve Sanders, Ben Mouncer and Lewis Davies and included rounds such as 'Tiger's Eighteen Holes' and 'Whelan or Fortune'.

In November 2012, One Media Radio's Head of Sport Edmund Doc Crosthwaite confirmed that Final Quizzle would return for a one-off Christmas special on 12 December 2012.

Featuring the band Busted answering questions about themselves, it was presented by Fearne Cotton who in each segment was dressed as Sue Barker.