[1] Prior to its creation, Quezon was once part of a vast track of agricultural land called the Mallig Plains and was sparsely populated.

[6] When Manuel L. Quezon was elected as the President of the Philippine Commonwealth, one of his administration's main programs was to promote development in the other areas in the country aside from Manila.

A few years after the declaration of the area as site for settlement and agricultural development, World War II broke out and the region was later placed under Japanese control.

Provincial officials, particularly Representative Delfin Albano of the lone district of Isabela saw the urgency and the need to create a new municipality out of Mallig.

Hildebrando Pécson was appointed as the first mayor of the municipality from 1960 until 1967 when after his term limit allowed by law then, he was succeeded by Hermogenes Padilla in the 1967 local elections.

Due to term limit as stated on the 1987 Philippine Constitution and the Local Government Code of 1991, the position of mayor was left as an open race in the 1998 elections.

The municipal landscape of Quezon is characterized by a mixture of relatively flatlands punctuated at certain points by undulating and rolling terrain, with mountain ranges flanking its eastern and western sides.

The low-lying hills ad surrounding mountains ranges are slightly dissected by intermittent creeks and waterways, which act as natural drainage avenues of accumulated run off water coming from the uplands.

The central plain, where the Poblacion is located, has an elevation of about 100 meters above mean sea level, and is predominantly characterized by low relief and moderately sloping areas.

The south-western portion is characterized by the low-lying hills with undulating and rolling terrain, having elevations ranging from 90 to 120 meters above mean sea level.

Deep well areas generally consist of sedimentary formations, 90 percent of which are water carriers, These are usually located in slopes reaching up to 10%, usually at elevations of more than 50 meters above sea level.

Forest lands cover approximately 6.71 square kilometres (2.59 sq mi) or 2.5% of the total area and these are located on the eastern portion of the municipality.

Although the Sierra Madre flanks boundaries of Quezon, the predominance of relatively flat to moderately sloped area and the absence of imposing peaks prevent orographic precipitation.

As observed and recorded at the Agro-Meteorological station located in Minanga, Iguig, Cagayan, the town received an annual rainfall of 1,572.4 millimetres (61.91 in), 92.3 percent of which occurs from May to November.

This was attributed to the proximity of Quezon to the Mountain Province area and with the opening of Chico dam that made this downstream municipality as its irrigation's beneficiary.

This has a significant bearing on the sustainability of employment, an important indicator to measure the performance of a specific sector in particular and the economic status of the municipality in general.

Since the most dominant economic activity in the area is rice farming it would do the farmers well if they could venture into this type of enterprise since this will provide additional income for them.

These industries include a vinegar factory and a wood, and bamboo furniture and hut processing plant in barangay Santos, as well as rattan shop in Barucboc.

To cater to the personal needs of the local residents, there are a number of business activities, which provide such services as photo supplies, beauty parlors and video rentals.

Vegetables include eggplant, ampalaya, tomato, sweet potato, upo, beans, gabi, and pechay, okra, kalabasa, and mongo.

The work animals play an important role in land preparation for planting crops and hauling products especially those families who can't afford to buy hand tractors.

The hogs and goats numbering 7,664 and 977 respectively serve as part of the livelihood for additional income and supplementary source of protein for local residents.

Aside from reforestation projects, which involved the rejuvenation of forestlands, Quezon is also host to a number of Forest Land Grazing Lease Agreement.

The Santiago–Tuguegarao Road, also known as the Cagayan Valley National Highway, spans a contiguous length of 25 kilometers, which traverses through the center of Quezon and bisects the town.

DG Computer Net Cafe, located at Alunan, Quezon, Isabela, serves as the primary source of the town's social connectivity.

The existing water supply facilities of Quezon are a crude mix of deep and shallow wells with some areas having developed spring catchments as reservoirs.

As to the construction materials of the outer walls, 34.45% percent of the occupied housing units 47.59% have bamboo / sawali / cogon / nipa and 7.6 had concrete / brick / stone and wood.

The head of the association is known as SK Federation President and is elected amongst youth council leaders in the municipality through a concession or majority vote.

Quezon, belonging to the fifth legislative district of the province of Isabela, currently represented by Faustino Michael Carlos T. Dy III.

Most people in this municipality invest their hard-earned income for the education of their children through farming, employment, small businesses or through the remittances of a family member working abroad.