[1] The Herald was purchased in September 1891 by three men from Rockford, Charles L. Miller, Hedley John Eaton and Edmund Botsford.

In June 2001, QNI purchased from Shockley Communications five ABC affiliates in Wisconsin: WKOW-TV in Madison, WAOW-TV in Wausau; WYOW in Eagle River (a satellite of WAOW); WXOW-TV in La Crosse; and WQOW-TV in Eau Claire (a semi-satellite of WXOW).

Concurrent with the Shockley purchase, KTTC entered into a shared services agreement with KXLT-TV, the Fox affiliate in Rochester, Minnesota.

On February 11, 2014, Quincy announced plans to acquire a number of small and mid-market stations from Granite Broadcasting, including WEEK-TV in Peoria, KBJR-TV in Superior, Wisconsin, KRII in Chisholm, Minnesota (a satellite of KBJR), and WBNG-TV in Binghamton, New York (the company's first CBS affiliate; WEEK and KBJR/KRII are NBC affiliates).

[9] In November 2014, the deal was reworked so that Quincy would acquire WISE and provide services to WPTA, retaining the arrangement between the stations established by Granite.

The NRHP-listed local landmark was the home of notable Quincy residents and institutions for over a century, now demolished.

[15][16] On August 29, 2018, Quincy Media's stations were pulled from Dish Network after failing to reach a new retransmission fee agreement.

[19][20][21] Two days later, on October 31, Quincy announced that it would be acquiring WSIL-TV in Harrisburg, Illinois and KPOB, Poplar Bluff, MO, from Mel Wheeler, Inc. for $24.5 million.

[22][23] On May 10, 2019, Quincy announced it would purchase the Hannibal Courier-Post from GateHouse Media, marking its first daily newspaper expansion since 1969.

[25] On January 7, 2021, television industry news website FTVLive obtained an internal memo from President and CEO Ralph Oakley confirming that Quincy Media had put itself up for sale.

[28] On April 29, it was announced that Allen Media Group will purchase 10 Quincy stations not being acquired by Gray Television for $380 million.

[29] The newspapers were sold to another family-owned publishing company, Phillips Media Group of Harrison, Arkansas, in a separate transaction.