[1] It is used for general aviation but also sees Southern Airways Express flights to Chicago's O'Hare International Airport and St. Louis Lambert International Airport, a service which is subsidized by the federal government's Essential Air Service program at a cost of $1,956,856 (per year).

[4] The airport has often played host to events held by the International Stinson Club, including fly-ins, job fairs, and more.

[1] For the twelve month period ending January 1, 2019, the airport had 19,444 aircraft operations, an average of 53 per day: 80% general aviation, 20% air taxi and less than 1% military.

In 1950, Trans World Airlines (TWA) was operating two daily Douglas DC-3 services with a westbound routing of Boston - Albany, NY - Pittsburgh - Chicago - Peoria, IL - Quincy - Kansas City - Topeka - Wichita and an eastbound routing of Kansas City - Quincy - Peoria - Chicago.

[20] According to the Official Airline Guide (OAG), by 1981 Ozark was operating all of its Quincy flights with McDonnell Douglas DC-9-30 jetliners with four departures every weekday on non-stop flights to St. Louis and Burlington as well as direct, no change of plane jet service to Chicago O'Hare Airport, New Orleans and Rockford, IL with direct one stop DC-9 service being operated from Kansas City.

[24] The airport was also formerly served by Trans World Express operated by Air Midwest in 1989 with Swearingen Metroliner commuter propjets and later by Trans States Airlines from the early to mid 1990s with British Aerospace BAe Jetstream 31 and Swearingen Metroliner commuter propjets with both airlines operating these services via respective code sharing agreements on behalf of Trans World Airlines (TWA) with nonstop flights from the TWA hub in St. Louis.

On November 19, 1996, United Express Flight 5925 from Chicago via Burlington, Iowa, crashed on landing at Quincy.