A small group of Franciscan friars left Germany in 1858 to serve the German-speaking population in what was then the frontier state of Illinois.

Anselm Mueller, who served as president for a total of 37 years beginning in 1863, the institution moved to its current location on what is now College Avenue.

From its founding, Quincy University has embraced a deep commitment to the liberal arts while recognizing the importance of professional programs.

From the 1870s until the 1950s, the great majority of campus courses and activities occurred in Francis Hall, a large building renowned for its beauty and strong German architectural influences.

[8] In November 2018, the institution received $2.25 million from the U.S. Department of Education to expand students' access to science, technology, engineering and math.

The program also emphasizes high-impact learning experiences, such as undergraduate research and internships, along with multiple sources of mentoring and advising.

New or updated and renovated laboratories in computer science, cybersecurity, business analytics, biology, and chemistry are available, as is the John “Pete” Brown Mock Trial courtroom.

The campus also features distinctive examples of Mid-Century modern architecture in its residence halls and classroom and administration buildings.

The Brenner Library includes the highly regarded Gray Gallery, which features art exhibitions throughout the year.

Now called the North Campus, this extensively renovated facility houses most of the Division of Science and Technology, the Connie Niemann Center for Music,[12] and the Quincy Media Inc. television studio.

Campus life at Quincy University involves several student clubs and activities, including three Greek-letter organizations.

Following a procession by the faculty in academic regalia, the ceremony takes place in St. Francis Solanus Church, a Franciscan parish located across the street from Quincy University.

Quincy University is a member of NCAA Division II and has been a part of the Great Lakes Valley Conference (GLVC) for most sports since the 1995–96 school year.