In addition to Quinlan, the district serves the towns of West Tawakoni and Hawk Cove, most of Union Valley, as well as rural areas in southern Hunt County.
A small portion of northern Kaufman County also lies within the district.
The district covers a total area of 152 square miles (390 km2).
The student population is approximately 2,600 (68% Anglo, 27% Hispanic, 2% African-American, <1% Asian, and <1% Native American).
QISD's mascot is the panther, and the school colors are blue and white.