[3] Founded in 1963, QCC occupies a campus within the Greendale neighborhood of Worcester, which was formerly owned by the Assumption Preparatory School until it was destroyed by an F4 tornado in 1953.

The college maintains twelve satellite campuses in locations such as nearby Marlborough and Southbridge.

QCC has a Center for Workforce Development and Continuing Education, which offers low-cost training programs that enable individuals to learn new skills that can be applied on the job or used for future professional development.

The center works closely with local companies and organizations to meet specific organizational goals.

[7] Individual programs of study are also fully accredited by specific agencies such the American Dental Association, the American Occupational Therapy Association, the Commission on Accreditation of Allied Health Education Programs, the National Association for the Education of Young Children, and the National League for Nursing.