With a land area of 12,130 km2 (4,680 sq mi), it is the second-largest commune of France.

[5] Following the construction of a bridge over the Approuague River in 2003, an asphalted road from Régina to Saint-Georges de l'Oyapock (a town by the Brazilian border) was opened in 2004, completing the road from Cayenne (the préfecture and largest city of French Guiana) to the Brazilian border.

It is now possible to drive on a fully paved road from Saint-Laurent-du-Maroni on the Surinamese border to Oiapoque, Brazil.

[7] In 1998, the Kaw-Roura Marshland Nature Reserve was established, and covers an area of 94,700 hectares between Roura and Régina,[8] and is sometimes nicknamed "the Everglades of Guyana".

[9] The Petite Montagnes Tortue Biological Reserve is located the commune.