She is attributed with the invention of the modern-day discothèque,[8] by virtue of creating a new dynamic atmosphere at Paris' Whisky à Gogo, with the ubiquitous jukebox replaced by disc jockeys utilizing linked turntables.

[9][failed verification] In 1958, she opened Chez Régine in the Latin Quarter of Paris, which became the place to be seen for visiting celebrities, socialites and royalty.

[14] They split their time living between Paris and a penthouse suite at the Delmonico Hotel on Park Avenue and 59th Street in New York.

[17][18] In the 1970s, Zylberberg also designed a line of "Ready-to-Dance" evening clothes that were proof against wrinkling and so could be packed, which were sold at Bloomingdale's.

[19] On 22 April 1996, Zylberberg and her son were arrested for refusing to comply with crew requests and smoking on an American Airlines flight.