Río Blanco (Spanish for white river) is a river in the municipality of Ponce, Puerto Rico.

It is located in the northeastern area of the municipality.

[5] Together with the Río Prieto, the Río Blanco is one of the two rivers in Ponce with their mouth at the highest elevation (both at 1,381 feet).

The Río Blanco originates in the mountains of barrio Anón in Ponce,[6] right at the foot of PR-143, in the Toro Negro State Forest,[7] and cuts through the northern mountains of Barrio Anón.

After this it runs for about 0.2 kilometer before it feeds into Río Prieto, some 800 feet southwest of the intersection of PR-139 and Camino La Poblada.