Born in Ibirubá, Rio Grande do Sul, Guedes started his career with Grêmio's youth setup, but was released in 2011.

[1] Guedes made his first team debut on 23 November 2014, coming on as a half-time substitute in a 1–1 away draw against Flamengo in Série A; he also assisted Cléber Santana for the equalising goal.

On 5 April 2016, Guedes signed a five-year contract with Palmeiras in the top tier;[4] Verdão paid R$ 2.5 million for 25% of his federative rights.

[5] He made his debut for the club 14 days later, replacing Alecsandro in a 2–0 Campeonato Paulista home win against São Bernardo FC.

On 13 July 2018, Guedes was loaned to Chinese Super League side Shandong Luneng Taishan for one year with an obligation to buy for €9.6 million.