Murphy released her fifth and sixth solo albums Róisín Machine and Hit Parade, which received critical acclaim, in 2020 and 2023, respectively.

[14] Heather Phares of AllMusic described the album as combining elements of trip hop and funk with electronic dance music, using a more-humorous approach than some of their contemporaries.

[12] Instead of paying Dlugosch, Murphy helped write "Never Enough",[20] which reached number sixteen on the UK Singles Chart in June 2001.

No official statement about Moloko's future was issued but Murphy told Q magazine in May 2005: We left it on good terms after a very successful tour.

[citation needed] In 2004, Murphy recorded her first official solo material with producer Matthew Herbert, who had previously remixed tracks for Moloko.

Murphy wanted to work with Herbert again, commenting: "it felt very natural ... because Matthew makes things seem quicker and easier".

[25] The album samples sounds made by everyday objects and actions, including cosmetics, brass mice, dancing and ornaments.

[27] Although the album was a commercial failure,[28] it drew mainly positive reviews; Pitchfork Media called it "perfect, the ultimate combination of human warmth and technological know-how".

The single was written by Murphy and Paul Dolby (Seiji) of Bugz in the Attic, and mixed by Tom Elmhirst, and was accompanied by a series of remixes from Seamus Haji, Kris Menace, Hervé and Loose Cannons.

[citation needed] In September 2007, Murphy received a pre-nomination for the MTV Europe Music Award for Best Inter Act, but did not make it to the final list.

[33] In the same year, she recorded a cover of Bryan Ferry's song "Slave to Love" that featured in a campaign for Gucci[17] and was released on the promotional single "Movie Star".

[34] In 2009, Murphy previewed material at the SeOne club in London, performing "Momma's Place" and "Hold up Your Hands", and in November, she premiered the single "Orally Fixated" on her Myspace page.

[citation needed] From 2010 until early 2013, Murphy contributed vocals to Crookers's album Tons of Friends;[35][36] David Byrne and Fatboy Slim's project Here Lies Love;[37] Mason's '"Boadicea"; Tony Christie's "7 Hills"; The Feeling's "Dance for the Lights"; an anonymous producer's song "Simulation";[38] "Golden Era"[failed verification] by David Morales;[39] "Flash of Light" and "Invisions" with Luca C & Brigante; "Look Around You" by Boris Dlugosch; "Alternate State" by Hot Natured; Freeform Five's "Leviathan"; and "In My Garden" with Invisible Cities[citation needed].

[44]Her July 2016 album Take Her Up to Monto[45] was recorded during the same sessions as Hairless Toys, and includes contributions from Murphy's long-time collaborator and producer Eddie Stevens.

[49] In 2018, The Vinyl Factory released a series of four 12-inch (30 cm) discs that Baltimore house-music pioneer Maurice Fulton produced.

[54] The album has ten tracks, including the singles "Simulation" and "Jealousy" that were released several years prior, and the more-recently produced songs "Incapable", "Narcissus", "Murphy's Law", and "Something More".

[64] Electronic Beats described Murphy as "this adolescent century's true art-pop queen"; and said "her sensuous and ominous output is scattered across various genres and moods" and "her reputation for sporting avant-garde couture into a place among fashion's elite".

[6] AllMusic described Murphy as "a purveyor of adventurous, omnivorous pop that blended influences as far-flung as disco and hot jazz".

[65] According to Drowned in Sound's Giuseppe Zevolli, Murphy has "merged pop, house, and disco with an avant-garde sensibility and a stunning, shape-shifting visual output that never ceases to provoke".

[68] According to Elizabeth Vincentelli of The New York Times: "it was only after [Moloko's] breakup that Murphy truly refined her trademark fusion of glossy sheen and playful experimentation".

[69] Murphy's diverse solo work includes collaborations with experimental jazz composer Matthew Herbert and electronic producer Eddie Stevens, drawing on house music, ballroom culture and avant-garde electronica.

[82][83] Her statements were met with backlash on social media, including responses from LGBT+ allies and activists accusing her of transphobia and misinformation.

[84][85][86] In the weeks following the comments, Murphy's material was removed from a scheduled BBC Radio 6 Music line-up, which had been due to broadcast five hours of her songs, interviews, and concert highlights.