[3] Grube started his career in 1989 at Messerschmitt-Bölkow-Blohm and went on to work in a number of posts at DaimlerBenz including senior vice president and head of corporate strategy.
[5] On April 25, 2009, Grube signed a five-year contract to succeed Hartmut Mehdorn as CEO of Deutsche Bahn AG, starting from May 1, 2009.
[5] In 2015, after the longest driver strike in the company's history, Grube launched another restructuring to cut costs and modernize the rail system.
The board had been prepared to offer Grube a two-year renewal of his contract, but he was seeking a three-year extension as well as a pay rise.
In July 2017, financial advisory firm and asset manager Lazard appointed Grube as chairman of investment banking in Germany.