Tilleur-Saint-Nicolas was a Belgian football club from the municipality of Saint-Nicolas, a suburb of Liège.
Tilleur only won three games in 1926–27 and finished last with 8 points, and was relegated back to the second division.
The club earned promotion to the first division for 1928–29, but finished last with 9 points, again being relegated.
Tilleur later had three extended spells in the first division: 1942–46 (interrupted by World War II in 1945), 1949–59 and 1964–67.
In 1995, the matricule n°21, along with its previous records, ended when the club merged with the elder (founded 1892) R.F.C.