Later in his life, despite having little formal training in the field, he turned his interests to the study of hallucinogenic mushrooms, religion, and ethnomycology, publishing papers that received attention and acclaim.

That same year, he published a book[6] on the Hall Carbine Affair, in which he attempted to exonerate John Pierpont Morgan from guilt with respect to the incident, which had been viewed as an example of wartime profiteering.

[10][11] Wasson's studies in ethnomycology began during his 1927 honeymoon trip to the Catskill Mountains when his wife, Valentina Pavlovna Guercken, a pediatrician, chanced upon some edible wild mushrooms.

[13] Though he faced no consequences for his deceptions, and indeed, profited greatly from the knowledge he gained from her, Sabina was subsequently ostracised from her community as a result of his actions, and her house was burned down after she was briefly jailed, her son murdered, and she eventually died in poverty.

[12] At the 1951 annual meeting of the American Council of Learned Societies, held in Rye, New York, on January 24-26, Wasson was appointed a member of the Executive Committee for a period of one year.

Six days later, his wife Valentina's first-person account of their research expedition in Mexico was published on the cover of This Week, a Sunday magazine inserted in 37 newspapers that reach almost 12 million total readers.

Wasson's next major contribution was a study of the ancient Vedic intoxicant soma, which he hypothesized was based on the psychoactive fly agaric (Amanita muscaria) mushroom.

In The Road to Eleusis: Unveiling the Secret of the Mysteries (1978), co-authored with Albert Hofmann and Carl A. P. Ruck, it was proposed that the special potion "kykeon", a pivotal component of the ceremony, contained psychoactive ergoline alkaloids from the fungus Ergot (Claviceps spp.).

[29] The first "Gordon and Tina Wasson Award" was presented to Paul Stamets on July 29, 2015, by the organization's former president, D. Jean Lodge, during the MSA meeting in Edmonton, Canada.