He moved to Hollywood in 2006, and worked with a personal talent manager to find acting opportunities where his disability could educate viewers.

[2] After making cameos in sitcoms, he was cast in his breakthrough role as Walter White Jr. on the AMC crime drama series Breaking Bad (2008–2013).

He was diagnosed with cerebral palsy at the age of three, and doctors put his legs in casts for six months in an attempt to straighten his feet.

[5] Mitte was fitted with leg braces and used crutches throughout most of his childhood; however, over time, his body became stronger through sports and exercise; he no longer needed any walking devices by his teenage years.

[6] In 2006, he moved with his family to Los Angeles, where his younger sister Lacianne Carriere had received an offer for a role in a film project.

[9] After receiving several roles as an extra, including in the Disney series Hannah Montana,[10] Mitte became interested in films and decided to take acting lessons.

In January 2014, he began a recurring role on the ABC Family drama series Switched at Birth portraying Campbell, a premed student paralyzed from a snowboarding accident who uses a wheelchair.