After graduating from high school, Anthony went on to attend Western Kentucky University where he would later start his music career.
In 1997, while attending Western Kentucky University, R. Prophet joined Skinny DeVille, B. Stille, Ron Clutch, Big V and Fish Scales to complete Nappy Roots, an American alternative Southern rap group.
The album includes the singles "Headz Up", "Awnaw" and Grammy nominated "Po' Folks" featuring Anthony Hamilton.
Discussing the meaning of "Po' Folks," R. Prophet told MTV.com that the lyrics did not only speak of being poor as an economic issue.
Also in 2003, R. Prophet was among a group of celebrities and professional athletes who participated in USO Project Salute 2003, a tour that made stops throughout the Persian Gulf including Iraq.
[citation needed] In 2007, R. Prophet went on to pursue his solo career, traveling to Houston, Texas to record his first single, "Run Tell The DJ To Crank it" with former Cash Money producer Mannie Fresh.
R. Prophet performed on-stage with the likes of Nelly, Ludacris, T.I., Young Buck, and Yung Joc.
[citation needed] On April 20, 2013, Prophet was beaten, tased and arrested by Kentucky State Police, who told TMZ he was highly intoxicated, walked directly into traffic and was a danger to himself and others.