The Russian route R22 (also known as the Caspian Highway) is a major trunk road that links Moscow to the Caspian Sea.

The road runs from Stupino, then heads southeast across Ryazan Oblast, Tambov Oblast, Voronezh Oblast, and Volgograd Oblast, running along the right bank of the Volga River through Volgograd before terminating at Astrakhan.

The entire route is part of European route E119, the stretch between Volgograd and Astrakhan is also part of European route E40, and the stretch between Borisoglebsk and Saratov is also a part of European route E38.

The section from Kashira to Astrakhan is part of AH8, the section from Saratov to Borisoglebsk is part of AH61, and the section from Volgograd to Astrakhan is part of AH70.

In 2018, the northern terminus was moved to the M4 south of Stupino, removing the concurrency with the M4.