Within the agglomeration of Brno plans for a new route intend to relocate the D52 running from the Rajhrad junction bypassing the city centre to reach the Highway D1 and the Expressway R43 at Troubsko.

[2] A 22.5-kilometre-long (14.0 mi) section between Pohořelice and Mikulov is planned for 2028,[3] providing a continuous connection between Brno and the Austrian A5 (North Autobahn) at Drasenhofen, leading to Vienna.

On 23 January 2009, an agreement was signed in Vienna between the Czech Republic and Austria on the connection of the R52 expressway with the Austrian A5 motorway on the Brno-Vienna route in the Mikulov-Drasenhofen section (in the area of the former border crossing).

The construction of the R52 was supposed to start in 2010, but on the petition of the municipalities of Bavory and Dolní Dunajovice and several individuals, the Supreme Administrative Court annulled the zoning plan of the Břeclav region in November 2009, including the disputed R52 route between Pohořelice and Vienna.

[5] The European Commission also criticised the procedure of the Czech authorities in approving the zoning plan of the Břeclav region and refused to co-finance the construction until the situation was clarified.