The R59 is a provincial route in South Africa that connects Hertzogville with Alberton (south-east of Johannesburg) via Bothaville, Parys and Vereeniging.

[2] North of the town, the R59 becomes its own road north-east, heading for 50 kilometres to Hoopstad where on the southerly outskirts, before the Vet River, it meets the northern terminus of the R700 at a t-junction and turns northwards.

[2] The route continues north-east for 55 kilometres, past a place named Misgunst, to reach a t-junction with the R30 and co-sign with it northwards, crossing the Vals River into the town centre of Bothaville.

[2] It continues north-east for 12 kilometres to Parys, where it becomes the main road through the town (Bree Street) and meets the southern terminus of the R53 and R500 routes from the North West Province (which the nearby, parallel Vaal River forms the border with).

[1] It proceeds east-north-east for 20 kilometres, still following the Vaal River, to enter Sasolburg's northern suburbs, where it forms a large interchange with the R57 Golden Highway.