USAAF Station Units assigned to RAF Glatton were:[1] The airfield was first used by the 457th Bombardment Group (Heavy), arriving from Wendover AAF, Utah on 21 January 1944.

Until June 1944, the Group engaged primarily in bombardment of strategic targets, such as ball-bearing plants, aircraft factories, and oil refineries in Germany and Occupied Europe.

After V-E Day, the 457th transported prisoners of war from Austria to France, and returned to Sioux Falls AAF, South Dakota during June 1945 and was inactivated on 18 August 1945.

3 Group under the control of RAF Bomber Command using Avro Lancasters and Consolidated Liberators flying to the Middle East.

The churchyard of All Saints Church in Conington contains a memorial to the men of the 457th Bomb Group who lost their lives on missions that flew from Glatton.