REGNUM covers events in all regions of Russia as well as neighboring countries in Europe, Central Asia and the South Caucasus.

REGNUM press centers are located in Moscow, Saint Petersburg, Pskov, Arkhangelsk, Vologda, Barnaul, Krasnoyarsk, Novosibirsk, Kaluga, Yerevan (Armenia).

[10] Estonia's Security Police (KaPo) in its 2005 yearbook laid a claim according to which REGNUM had been designed as a tool in Russia's state propaganda machine operating under direction of Modest Kolerov, at the time the head of an agency within President Vladimir Putin's administration.

[11] As Russia's foreign policy tool REGNUM has been instrumental in encouraging opposition to energy independence plans in the Baltic states, contributing to the negative popular vote on the question of a new nuclear power plant in Lithuania.

In a report circulated by the Ministry of Foreign Affairs of Turkmenistan, Turkmen diplomats repeatedly expressed their dislike of the agency, claiming that it systematically disseminates inaccurate, biased information about their country.

Citizens of Belarus Dmitry Alimkin, Yury Pavlovets and Sergey Shiptenko spent 14 months in pre-trial detention center No.