RK Alkaloid (Macedonian: РК Алкалоид) is a Macedonian team handball club from Skopje, that plays in the Macedonian Super League and EHF European Cup.

The club was founded on 7 July 2021 and immediately started competing in the second tier of Macedonian Handball.

[1] RK Alkaloid started competing in the Macedonian First League in the 2021–22 season and managed to win the league title in their first season, securing a place in the Macedonian Handball Super League for the 2022–23 season.

[2] They finished 2nd in the 2022-23 Macedonian Handball Super League season and they competed in the EHF European League group stage for the first time in the season 2023-24.

[3] Avtokomanda Hall the indoor sports arena located in Skopje, Avtokomanda.