Representational oligonucleotide microarray analysis

Representational oligonucleotide microarray analysis (ROMA) is a technique that was developed by Michael Wigler and Rob Lucito at the Cold Spring Harbor Laboratory (CSHL) in 2003.

[citation needed] Wigler and Lucito currently run laboratories at CSHL using ROMA to explore genomic copy number variation in cancer and other genetic diseases.

After analysis of the ROMA microarray image is completed, a copy number profile of the entire human genome is generated.

Jonathan Sebat was one of the first researchers to report in the journal 'Science' in 2004 that these CNPs give rise to human genomic variation and may contribute to our phenotypic differences.

[1][citation needed] Tremendous research efforts are being conducted now to understand the role of CNPs in normal human variation and neurological diseases such as autism.