One of the pillars of a political consolidation in Venezuela, the Pacto de Punto Fijo, was underestimated by Leoni, since in his opinion it reduced the "coherence and organization of the regime".

Leoni made an attempt at reforming tax structure, but was restrained by a coalition of left and right that openly served the interests of oil companies.

During Leoni's presidency the conflict with the leftist guerrilla movement Armed Forces for National Liberation (FALN) intensified.

Ochoa with the Venezuelan guerrilla commander Luben Petkoff, took a boat to the shores of Falcon, Venezuela, one of his most secretive expedition.

Along with 15 other members of the Cuban military went to Coro Sierra mountains to strengthen Douglas Bravo guerrillas who were fighting the government troops that ended in a major strategic loss at large human cost.

The precursor to the Andean Community, it was a trade bloc in Bogotá between Venezuela, Chile, Colombia, Peru, and Ecuador.

On 11 March 1969, Leoni transferred power to Rafael Caldera, a member of the Christian Democratic Party COPEI and a signatory of the Pacto de Punto Fijo.