[7][8] Radhika made her cinematic debut in the 1978 Tamil movie Kizhakke Pogum Rail after accidentally meeting Bharathiraja.

[11][12][13] After becoming successful in cinema, Radhika wanted to do something different and decided to take on the small screen, a venture that everyone thought was a mistake and one she would regret.

But determined to pursue something she believed in, namely producing television serials under her own banner, she started Radaan Mediaworks in 1994.

[14] She produced serials such as Idi Katha Kadu (Telugu), Chitti, Annamalai, Selvi, Arasi, Chellamay, Vani Rani, Thamarai and Chithi 2.

[citation needed] In the 2024 Indian general election, Radhika contested as the BJP candidate from the Virudhunagar Lok Sabha constituency.

In 2014, Radiance Media Private Ltd. filed a petition claiming that Magic Frames, a company where Radhika and her husband Sarathkumar are partners, borrowed ₹1.50 crore and later her husband Sarathkumar took an additional loan of ₹50 lakhs in an agreement that the amount would be returned by March 2015.

[22] The Income Tax department conducted a raid on Radaan Mediaworks India Limited, a media company owned by Radhika Sarathkumar, in Chennai on 11 April 2017, days after the department interrogated her husband Sarathkumar and searched his house.