She made her feature film debut in Woody Allen's Alice (1990), and came to prominence with her portrayal of Michelle Bauer on the CBS soap opera Guiding Light (1990–1995).

Outside film, Miner is known for her recurring portrayals of Dani on Showtime's Californication (2007–2008), Dawn Trager on FX's Sons of Anarchy (2011–2012), and Meg on The WB's Supernatural (2009–2020).

[4] In a 1993 interview, Miner named Jodie Foster as the actress she most admired, and expressed the hope that she might have the opportunity to tackle a similar range of roles.

[2] Miner's television credits include Vickie in Shining Time Station: 'Tis a Gift (1990), Michelle Bauer on Guiding Light (1990–1995), a guest starring role as Laurel in a Sex and the City episode, "Twenty-something Girls vs. Thirty-something Women" and Astrid in NY-LON.

[7] In 2005, Miner portrayed a young woman on a journey to discover who she is and why multiple enemies want her dead in the action film Circadian Rhythm.

The writers wanted Meg's original actress Nicki Aycox to reprise the role in later seasons, but ultimately cast Miner for storyline purposes.

[13] Similarly, Diana Steenbergen of IGN felt Miner played the role "with vicious flair" and "[conveyed] Meg's brutality well, right from the beginning".

[15][16][17] In 2020, Miner returned to Supernatural during the fifteenth season playing the character of a cosmic entity known as the Empty that takes Meg's physical appearance.