[3] The Bishops Gallery, comprising 60 portraits painted by Vatican artist Luigi Gregori, and the Museum of Indian Antiquities were established in 1875 in the Main Building of the University of Notre Dame.

As a result the second floor spaces of Bond Hall were renamed in her honor as the Wightman Memorial Art Gallery.

[2] A donation in 2018 from lead benefactors Ernestine Raclin and her daughter and son-in-law Carmen and Chris Murphy provided the necessary funds for the construction of a new museum complex to house the University's art collection.

[2] Construction of the first phase began in April 2020 and the Raclin Murphy Museum of Art was opened in the completed building on 1 December 2023.

The museum also includes commissioned works from Jenny Holzer, Kiki Smith, Maya Lin, Magdalena Abakanowicz, Zhang Huan, Julie Mehretu, Jamie Okuma, Yinka Shonibare, and Ursula von Rydingsvard.

[7][better source needed] The museum's collection is displayed in 23 historically themed galleries placed around a multi-level atrium that rises to a central skylight.