The women's singles event in racquetball at the 2022 World Games took place from 10 to 13 July 2022 at the University of Alabama Birmingham in Birmingham, United States.

[1] Mexican Paola Longoria won the competition, defeating Guatemalan Gabriela Martinez in the final.

[2] A total of 16 athletes entered the competition.

They competed in knock-out system.

- Racquetball at the 2022 World Games - Men's singles