The album features guest appearances from Shawty Fatt, Mystikal, Kid Rock, Lil Jon, Rittz, Gangsta Boo, Eminem, Poo Bear, Priscilla Renea, Fefe Dobson, Mona Moua and Killer Mike.

Hardcore hip hop is represented on the tracks "Radioactive Introduction", "Throw It Up", "Get Away", and "Slumerican Shitizen".

A horrorcore rap style is used in "Growin' Up in the Gutter", whereas "Hard White (Up in the Club)" is a crunk party track.

"Let's Roll", "Write Your Name", and "Radio" follow a pop rap style, with catchy hooks and beats.

"Good Girl" utilizes an R&B-tinged feel, while "The Hardest Love Song in the World" is a g-funk hip hop track.

[8] It was directed by Tyler Clinton and Yelawolf credited as Michael Wayne for Slumerican, the short film was titled "Gutter".

Prefix Magazine stated that it was "hard to view Radioactive in any context that doesn’t label it as a total artistic failure" and that Yelawolf was "rolling over to commercial demands".

[21] PopMatters echoed this sentiment, calling the album a "misguided grasp at populism" and criticising Yelawolf's willingness to "play second fiddle" to A&R demands.