Bryan Lee O'Malley attended St. Thomas Aquinas Catholic Secondary School in London, Ontario, Canada.

[1] Prior to having his own material published, O'Malley illustrated the Oni Press miniseries Hopeless Savages: Ground Zero, written by Jen Van Meter.

Lost at Sea is a coming-of-age story about a shy 18-year-old girl named Raleigh, who believes her soul was stolen by a cat, and the road trip she takes across the United States with several teens from her school that she barely knows.

From 2004 to 2010, O'Malley worked on the six-volume Scott Pilgrim series, published by Oni Press in digest size black and white books.

[10] O'Malley is also a songwriter and musician (as Kupek) and was formerly in several short-lived Toronto bands such as Imperial Otter and Honey Dear.