She served as Columnist, Senior Diplomatic Correspondent, and New York Bureau Chief for the London-based Al-Hayat daily for 28 years.

[6] Dergham was first hired professionally as a journalist in Boston, beginning her career in radio in 1974 and hosting a program Haneen (Translated: Nostalgia), and from this start, she became a foreign correspondent in New York in 1976.

[6][7] In addition to being a regular political commentator on CNN, she has made frequent appearances in other international TV and radio broadcast forums.

She has interviewed many notable figures including: She covered the US-Soviet Summits in the 1980s between US President Ronald Reagan and Soviet General Secretary Mikhail Gorbachev.

Raghida Dergham was one of three Arab-Americans featured in the PBS documentary Caught in the Crossfire: Arab Americans in Wartime which aired on September 4, 2002.

The government of Lebanon has shown contempt for press freedom and the free public debate that is essential in a democratic society.

In 2018, Raghida Dergham was ranked among the FORBES Middle East Top 35 Influential Lebanese Business Personalities.