[8] Panjabi is the co-founder and former CEO of Last Mile Health and has served as Assistant Professor of Medicine at Harvard Medical School (part-time) and Brigham and Women's Hospital, visiting faculty at Harvard's Kennedy School of Government, and Advisor to former Liberian President Ellen Johnson Sirleaf, co-chair (with former New Zealand Prime Minister Helen Clark) of the Independent Panel for Pandemic Preparedness and Response.

He was a Clinical Fellow at Harvard Medical School, and trained in internal medicine and primary care at the Massachusetts General Hospital.

As White House Senior Director for global health security and biodefense and Special Assistant to the President of the United States, Panjabi played a pivotal role in the largest vaccination campaign in history against COVID-19, and White House responses to public health crises, including Mpox, Influenza, Ebola, and Marburg.

[17] Panjabi also helped oversee implementation of the President's 2022 Executive Order on Advancing Biotechnology and Biomanufacturing Innovation, which directed federal agencies to drive research and development, streamline regulation, grow manufacturing, and expand markets for biotechnology products, including by leveraging artificial intelligence and synthetic biology.

[20] He co-developed the President's COVID-19 and health security initiatives with the G7, G20, European Union, ASEAN, Quad (India, Australia, Japan, U.S.), CARICOM, and African Union, including efforts to organize Presidential Summits,[14] launch the Pandemic Fund at the World Bank, negotiate the Pandemic Accord at the World Health Organization, and uphold the United Nations' Biological Weapons Convention.

Panjabi served as technical advisor to former President Ellen Johnson Sirleaf in her role as co-chair of the WHO Independent Panel for Pandemic Preparedness and Response.

"[26] Panjabi is the co-founder and former CEO of Last Mile Health,[27] an enterprise leveraging digital technology to train thousands of healthcare providers serving millions of people.

[28] He co-founded this organisation in 2007 with a small team of Liberian civil war survivors and American health workers and $6,000 (~$8,817 in 2023) he had received as a wedding gift.

[30] As CEO of Last Mile Health, Panjabi led key efforts in response to 2013-16 Ebola epidemic in West Africa and the COVID-19 pandemic.

Panjabi and the Last Mile Health team played a significant role in the 2013-16 West Africa Ebola epidemic, helping train over a thousand frontline and community health workers, mobilize hundreds of tons of personal protective equipment and support the Government of Liberia to organize and lead its National Ebola Operations Center.

He and Last Mile Health received Clinton Global Citizen Award, along with a coalition, for leadership in response to the 2013-16 West Africa Ebola epidemic.

Panjabi trained and worked as a clinical provider in community health systems in rural Alaska, North Carolina and Massachusetts.

[45] Panjabi highlighted the role of investing in rural community health workers at the TIME-Fortune Global Forum hosted by Pope Francis in 2016.

These organizations include venture backed health technology companies, Merck for Mothers, Johnson & Johnson Global Public Health, the Global Fund for AIDS Tuberculosis and Malaria (as part of the U.S. constituency), the U.S. President's Emergency Plan for AIDS Relief (PEPFAR), the Bipartisan Commission on Biodefense (Ex-Officio Member), the Skoll Foundation, Echoing Green, Doctors for America, Last Mile Health, Ellen Johnson Sirleaf Presidential Foundation, Healthcare Without Harm and Practice GreenHealth, and the World Health Organization's Independent Panel for Pandemic Preparedness and Response, (as advisor to former Heads of State, Ellen Johnson Sirleaf of Liberia and Helen Clark of New Zealand).