Ramón Javier Mestre (Córdoba, Argentina, July 2, 1972), is an Argentine lawyer and politician for the Unión Cívica Radical.

He is son of Ramón Bautista Mestre (governor of Córdoba from 1995 to 1999; and mayor of the province capital city from 1983 to 1991).

In December of that year, he started his term as national senator.

On 18 September 2011, he was elected mayor of the city of Córdoba, against the dissident Peronist Olga Riutort (candidate for Alianza Fuerza de la Gente) and former vice-governor Héctor Campana (Unión por Córdoba).

Because of this, the UCR rules the city for the first time since 1999, the year in which Rubén Martí finished his term as mayor.