[4] Laureano finished 2016 with a combined .319 batting average along with 15 home runs, 73 RBIs and a .955 OPS in 116 total games between both teams.

He returned to Corpus Christi in 2017 where he posted a .227 batting average with 11 home runs, 55 RBIs and 24 stolen bases.

Instead of placing him on the 40-man roster to prevent his selection, the Astros traded Laureano to the Oakland Athletics in exchange for pitcher Brandon Bailey on November 20, 2017.

His first major league hit that night was a walk-off single to break a scoreless tie in the 13th inning against the Detroit Tigers.

[7] On August 20, 2018, he hit his first two major league home runs off Bartolo Colón in a 9–0 shutout victory over the Texas Rangers.

[9] On May 7, 2019, Laureano robbed Joey Votto of a home run in the sixth inning against the Cincinnati Reds, which would aid Mike Fiers's second career no-hitter.

[16] On August 6, 2021, Laureano was suspended by MLB for 80 games for testing positive for the performance-enhancing drug nandrolone.

[21] On July 11, 2022, Laureano misplayed a sinking line drive hit by the Rangers’ Josh Smith, resulting in an inside-the-park home run.

On January 13, 2023, Laureano signed a one-year, $3.55 million contract with the Athletics, avoiding salary arbitration.

On June 15, the Braves selected Laureano's contract, adding him to their active roster, after incumbent center fielder Michael Harris II suffered a hamstring strain.