He played in Major League Baseball (MLB) for the Anaheim Angels, Cincinnati Reds, Washington Nationals, Minnesota Twins, Colorado Rockies, Los Angeles Dodgers, Tampa Bay Rays, Chicago Cubs, and Toronto Blue Jays.

Ortiz also hit his first career home run in that game, a solo shot off of St. Louis reliever Jorge Sosa.

Ortiz was three outs away from becoming the fifth no-hit pitcher in Major League Baseball who had homered in the same game, joining Wes Ferrell (1931), Jim Tobin (1944), Earl Wilson (1962) and Rick Wise (1971).

He began the season as the third starter, behind Johan Santana and Boof Bonser and ahead of Sidney Ponson and Carlos Silva.

[3] On August 15, 2007, Ortiz was traded to the Colorado Rockies in return for minor leaguer Matt Macri.

On February 10, 2009, Ortiz signed a minor-league contract with an invitation to spring training with the San Francisco Giants.

Ortiz signed a minor-league contract with the Los Angeles Dodgers before the 2010 season, with an invitation to spring training.

After good performances in spring training games, he was added to the Dodgers Major League roster to start the season.

Ortiz had his contract purchased again by the Blue Jays on June 1 when Brandon Morrow was placed on the disabled list.

After pitching to a 2–1 count against Chase Headley, Ortiz suffered an apparent elbow injury and became visibly emotional, leaving the field in tears.

[13][14] Ortiz was placed on the 15-day disabled list with a right elbow strain on June 4, while the team awaited the results of an MRI.

[17] His season ended on the disabled list with a 1–2 record, 6.04 earned run average, and 8 strikeouts over 251⁄3 innings.