Ramón David Santiago Sanchez (born August 31, 1979) is a Dominican-American[1] former professional baseball infielder, and current manager for the Leones de Yucatán of the Mexican League.

He accomplished this feat playing with the Reds with two outs in the bottom of the 10th inning on September 27, 2014, on a 1–0 pitch from the Pittsburgh Pirates' Bobby LaFromboise.

Santiago struggled and was traded, along with minor league player Juan Gonzalez, to Seattle in exchange for Carlos Guillén.

During Santiago's two seasons with the Mariners, he played in only 27 games, spending most of his time in the minor leagues for the Triple-A Tacoma Rainiers.

During the Tigers run to the 2011 American League Central Division championship, Santiago played in 101 games, mostly at second base, and hit .260.

His season highlights included a walk-off home run on August 30, which gave the Tigers a 2–1 victory over the Kansas City Royals in the bottom of the 10th inning.

In a July 2013 game versus the Toronto Blue Jays, Colby Rasmus slid into second base, slide-tackling Infante, who was injured and placed on the disabled list.

[7] On September 27, he hit a walk–off grand slam in the 10th inning against Pittsburgh Pirates pitcher Bobby LaFromboise[8] in what would be the last at–bat of Santiago's Major League career.

Following the season on October 7, 2022, Santiago was removed from the major–league coaching staff and was offered a player development role within the organization.