[6] Yade joined the Union for a Popular Movement (UMP) political party in 2005 and became National Secretary in charge of Francophonie in 2006.

[6] In May 2007, Yade was appointed as Secretary of State for Human Rights under the Minister of Foreign and European Affairs, Bernard Kouchner.

In this capacity, she notably denounced Sarkozy's invitation to Muammar Gaddafi for state visit to France in 2008, citing the Libya's track record of human rights abuse.

[6] On 6 November 2007, Yade was among the guests invited to the state dinner hosted by U.S. President George W. Bush in honor of Sarkozy at the White House.

[8] On 9 December, Le Monde reported that Nicolas Sarkozy was "deeply disappointed" by her attitude and that she had "ruined all her chances" to succeed Jouyet.

[9] The following day, Foreign Minister Bernard Kouchner, in an interview with Le Parisien, said he regretted his suggestion to appoint a Secretary of State for Human Rights, although he noted that Yade had "done, with talent, what she could do".

[17][18][19] In 2012, Yade left the UMP, joined the Radical Party and supported Jean-Louis Borloo in the presidential elections until he decided not to run.

Rama believes that this ban should be decided "as a defense of secularism and the dignity of women" and calls on Muslims to "leave the literal text behind, and adjust to the times".

[29] In 2010, she called for a referendum on banning the full veil burqas in France, in order to circumvent any legal obstacles.

[31] She announced that she would appeal to the United Nations for the universal decriminalization of homosexuality, and asked, "How can we tolerate the fact that people are stoned, hanged, decapitated and tortured only because of their sexual orientation?

"[36] She said in 2013 interview that her support for same-sex marriage was consistent with her fight on equal rights and claimed that she had been designated as the most gay-friendly member of the government.

[37] On 1 February Rama Yade had signed with MP Yves Jégo, Jean-Christophe Lagarde, Senator Chantal Jouanno, an article in Le Monde in favor of gay marriage in the name of equality.

[36] On the issue of taxes, Yade has said "We're losing the rich, like Gérard Depardieu, and the poor feel betrayed," referring to workers at factories expected to close down.