In the late 14th century, the Yüreğir Turks moved to Cilicia and had a distinct culture with influence from Bektashi traditions of shamanic rituals along with Islam.

In addition, internal conflicts within the Armenian Kingdom made Türkmens turn their eyes to unstable Cilicia, and in 1352, Ramazan Beg led Turkmens to settle south of Çaldağı and founded their first settlement, Camili.

Later that year, Ramazan Beg visited Cairo and was assented by the Sultan to establish the new frontier Turkmen Emirate in Cilicia.

In 1359, Mamluk Sultanate Army marched into Cilicia and took over Adana and Tarsus, two major cities of the plain, leaving few castles to the Armenians.

The Ramadanids played an important role in 15th century Ottoman-Mamluk relations, being a buffer state located in the Mamluk al-'Awasim frontier zone.