In between, in 1981, he took a long leave of two years from the institute and did post doctoral research at the ETH Zurich[1][2] where he worked in the company of Professor Richard R. Ernst and Professor Kurt Wuthrich, who would eventually win Nobel Prize in 1991 and 2002 respectively.

[1] He is reported to have explained the folding hierarchy in HIV-1 protease, the native state energy landscape, and structural and dynamic characteristics of SUMO-1 protein along the equilibrium folding pathways and also shown experimentally that the progress of the native contacts is not monotonous.

[1] Hosur is reported to have developed a new NMR based theoretical model which is said to be of assistance in the structural studies on proteases.

He has also developed scaling techniques[5] for the enhancement of resolution and sensitivity and proposed what Indian Academy of Sciences quotes as:[1][5]a pH switch mechanism for cargo trafficking by DLC8 protein inside living cells.

[4] He is also an examiner for the award of PhD at the Indian Institutes of Technology, Bangalore, Mumbai and Delhi.

[4] Prof. Hosur has been appointed as a distinguished visiting professor in the Department of Biosciences and Bioengineering in IIT Bombay from 4 September 2018.

[4] Known as an efficient lecturer and honored by the Honorary Mention at the International Summer School on Quantum Chemistry held at Uppsala, Sweden during August–September, 1975,[4] Dr. Hosur is a recipient of several awards such as: The Government of India honored Ramakrishna Hosur with the Padma Shri by including him in the 2014 Republic Day Honours.