The village was home to the well-known poet Samih al-Qasim, the Greek Orthodox archbishop Atallah Hanna and artist Mira Awad.

South and southeast of the village, remains of building foundations were discovered, including an Aramaic inscription on a lintel, which indicate a 3rd to 4th-century synagogue.

[6][7] The inscription, consisting of two uneven lines of roughly incised Jewish script, is accompanied by reliefs depicting two cherub-like figures flanking a wreath.

[10] In 1517, Rameh was with the rest of Palestine incorporated into the Ottoman Empire after it was captured from the Mamluks, and by 1596, it was a village under the administration of the nahiya ("subdistrict") of Akka (Acre), part of Safad Sanjak, with a population of 96 households, all Muslim.

It paid taxes on silk spinning (dulab harir),[11] goats, beehives, and a press that was used for processing either olives or grapes, in addition to paying a fixed, or lump sum; a total 21,986 akçe.

[15] The following year, Rameh was noted as Christian and Druze village in the Shaghur district, located between Safed, Acre and Tiberias.

[29] Another Israeli unit entered the village during the next day and expelled 1,000 of its Muslim and Christian inhabitants on the threat of death, though the Druze were allowed to remain.

[30] The historian Benny Morris surmises that the expulsion order may have been driven by local Druze pressure to expel Rameh's Christians or a punitive response to the public support from one of Rameh's leading Christian notables, Father Yakub al-Hanna, for Fawzi al-Qawuqji, the leader of the Arab Liberation Army (ALA), one of the principal Arab forces in the Galilee during the 1948 Arab-Israeli war.

[30] Their return was likely enabled by the intervention of the Israeli officer Ben Dunkelman of the 7th Brigade, who protested the expulsion order.

Writing in the 1960s, the historian Jacob Landau noted that Rameh was "distinguished by its high level of education and standard of living, expressed in the home, dress and general behaviour".